Table 6.
Number of UC Patients and Number of Rectal Biopsies Required to Detect a Two-Fold Reduction in Gene Expression
| Number of Patients | ||||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Number of Biopsies | IL-1β | IL-6 | IL-8 | TNFα | IP-10 | CXCL-13 | MMP3 | S100A8 |
| 3 | 3 | 7 | 4 | 2 | 4 | >16 | 4 | 4 |
| 6 | 2 | 4 | 2 | 2 | 2 | 7 | 3 | 3 |
| 9 | 2 | 3 | 2 | 2 | 2 | 6 | 2 | 2 |
Using a linear mixed effect model with repeated measures, the power to detect twofold reduction in inflammatory gene expression from rectal biopsies was calculated. With a fixed number of biopsies before and after treatment, the minimum number of UC patients needed to obtain a power of 80% is reported.