Table 4.
Summary of PK parameters (mean ± SD, unless otherwise stated) at Cycle 1 Day 1 for blood BJP762 [28–70 mg/m2 (four highest doses of AUY922)]
| BJP762 PK parameter | AUY922 dose (mg/m2) | |||
|---|---|---|---|---|
| 28 (n = 5) | 40 (n = 3) | 54 (n = 6) | 70 (n = 8) | |
| T max [median, h (range)] | 1.07 (1.05–1.17) | 1.05 (1.05–1.07) | 1.08 (1.02–1.22) | 1.13 (1.00–1.23) |
| C max (ng/ml) | 611 ± 201 | 964 ± 775 | 1,060 ± 569 | 1,330 ± 904 |
| AUC(0–last) (h·ng/ml) | 3,700 ± 2,170 | 5,690 ± 5,250 | 6,320 ± 4,650 | 5,530 ± 3,320 |
| AUC(0–inf) (h·ng/ml) | 3,940 ± 2,320 | 5,830 ± 5,300 | 6,770 ± 5200a | 5,020 ± 3340b |
| T1/2 (h) | 59.1 ± 28.8 | 33.1 ± 12.1 | 49.1 ± 24.0a | 46.5 ± 27.9b |
PK pharmacokinetics, SD standard deviation
aData missing for one patient
bData missing for two patients