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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Immunol. 2014 Jun 27;193(3):1055–1063. doi: 10.4049/jimmunol.1301555

Figure 1.

Figure 1

Ultrastructural changes in plasma cells incubated with bortezomib. A. Normal plasma cells in control samples. Note the typical morphology, with elaborate endoplasmic reticulum (ER) and eccentric nuclei (with a cart-wheel heterochromatin configuration) B. Most plasma cells also appeared largely normal after 2 hours of treatment with 2.5 μM bortezomib. C. After 8 hours of treatment with bortezomib, most plasma cells appeared apoptotic, with heterochromatin condensed around the perimeter of the nucleus and distension of the ER lumen. After 24 hours with bortezomib, no plasma cells could be detected. Coded cell samples were post-fixed with osmium tetroxide and counter-stained with uranyl acetate and lead citrate. Pictures are representative of the conditions analyzed. Scale bars are 2 μm.