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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Immunol. 2014 Jun 27;193(3):1055–1063. doi: 10.4049/jimmunol.1301555

Figure 3.

Figure 3

Susceptibility of irradiated cells to experimental drugs. Thymic cells were irradiated and subsequently cultured for two weeks. Drugs were added on days 7 and 11 (bortezomib - 2.5 μM, lenalidomide −10 μM, dexamethasone - 10 nM) and samples were collected and analyzed as for Fig. 2.

A. Plasma cell survival from patients MG-1, 5 and 6 on day 14 shown as % of the absolute numbers in the control cultures (Table 2).

B. AChR autoAb secretion from patient MG-1 on day 11. The AChR autoAb production rate from patients MG-3, 5 and 6 was below detection limit; in MG-2, it was just above background.

C. IgG production rate from irradiated samples on day 14. Each point represents one well (3 per condition) from the indicated patients; horizontal bars are median values. One-way ANOVA and Bonferroni post-hoc testing were used for statistical analyses.