Table 3. Association between serum testosterone level and methadone-related factors.

	Total (n = 231)				Men (n = 131)				Women (n = 100)
Variable	Estimated β	95% CI		p	Estimated β	95% CI		p	Estimated β	95% CI		p
Age (years)	−0.007	−0.018	0.003	0.16	−0.008	−0.022	0.006	0.27	−0.007	−0.023	0.008	0.34
Sexe	1.034	0.857	1.211	<0.001a
Age of initial opioid use (years)	0.001	−0.009	0.011	0.83	−0.001	−0.015	0.014	0.90	0.004	−0.011	0.018	0.64
Number of cigarettes per day	0.003	−0.005	0.011	0.45	0.011	0.000	0.021	0.05c	−0.011	−0.024	0.002	0.09
Methadone dose	−0.002	−0.003	−0.000	0.02c	−0.003	−0.005	−0.001	0.00b	0.001	−0.002	0.003	0.66
Duration on MMTf (months)	0.000	−0.002	0.003	0.89	0.002	−0.002	0.006	0.37	−0.002	−0.005	0.002	0.28
Polysubstance use	0.125	−0.064	0.314	0.19	0.101	−0.18	0.382	0.48	0.244	−0.004	0.493	0.05d
Illicit opioid use	−0.002	−0.006	0.002	0.32	−0.003	−0.009	0.003	0.36	0.002	−0.007	0.003	0.49

^aSignificant at the p < 0.001 level.

^bSignificant at the p < 0.01 level.

^cSignificant at the p < 0.05 level.

^dShows a trend; p = 0.050–0.099.

^eSex values not possible for subgroup analysis by sex.

^fMMT: Methadone Maintenance Treatment.