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. Author manuscript; available in PMC: 2014 Aug 26.
Published in final edited form as: Biosystems. 2008 Apr 4;92(3):270–281. doi: 10.1016/j.biosystems.2008.03.007

FIG. 2.

FIG. 2

The ratio of modified enzyme and its inactive form as function of the response R considering the Goldbeter-Koshland function (2). The sigmoidal behavior is highly nonlinear and provides a continuous switching behavior at k3R = k4. The parameters are chosen as specified in Appendix E.