Table 2. GWAS results.

	Discovery phase					Replication phase					Combined phase
Protein	H*	N	SNPs	P (best)	% Var Expl†	H*	N	SNPs	P (best)	% Var Expl†	H*	SNPs	P (best)	% Var Expl†	λ‡
IL-6RA	0.66	653	22	1.1 × 10−40	27.3	0.50	317	10	1.1 × 10−20	27.4	0.68	22	4.4 × 10−58	26.6	1.06
CXCL10	0.47	641	24	1.4 × 10−31	21.3	0.39	311	1	2.3 × 10−06	7.2	0.46	16	6.8 × 10−37	16.9	0.94
CCL24	0.71	653	17	2.3 × 10−28	18.7	0.79	317	4	5.3 × 10−11	13.6	0.78	30	2.0 × 10−36	16.4	1.09
MIC-A	0.40	363	25	2.1 × 10−17	19.8	0.54	174	14	3.7 × 10−04	7.3	0.52	19	5.3 × 10−16	12.2	1.25
CD40-L	0.27	640	14	1.3 × 10−16	10.7	0.39	315	13	2.1 × 10−10	12.8	0.33	22	1.1 × 10−25	11.5	1.13
CXCL5	0.41	653	8	7.7 × 10−16	9.9	0.62	317	5	1.5 × 10−10	12.9	0.51	8	4.3 × 10−26	11.5	1.06
hK11	0.33	628	5	3.7 × 10−15	9.8	0.08	310	5	4.3 × 10−04	3.4	0.24	15	5.3 × 10−18	7.9	0.98
Ep-CAM	0.54	653	18	2.1 × 10−14	5.2	0.50	317	8	1.4 × 10−09	11.6	0.57	24	6.7 × 10−16	6.7	0.97
IL-17RB	0.51	415	1	4.7 × 10−13	12.6	0.30	199	1	1.1 × 10−07	14.2	0.48	2	1.7 × 10−18	12.5	0.96
IL-12B	0.38	652	1	4.7 × 10−12	7.3	0.64	317	1	1.3 × 10−06	7.4	0.43	4	9.0 × 10−17	7.1	0.93
VEGF-D	0.29	652	21	8.7 × 10−10	5.8	0.39	317	21	6.9 × 10−08	8.8	0.36	36	1.1 × 10−15	6.6	1.01
E-selectin	0.44	639	4	8.9 × 10−10	5.7	0.70	306	4	1.3 × 10−08	10.6	0.56	6	5.0 × 10−16	7.0	1.01
MIA	0.25	648	4	1.6 × 10−09	5.6	0.55	316	4	2.0 × 10−09	11.4	0.37	7	6.8 × 10−17	7.2	1.05
MPO	0.43	646	1	3.8 × 10−09		0.22	317	0	9.0 × 10−01		0.39	0	6.1 × 10−07		1.05
CCL19	0.32	653	10	1.3 × 10−08	5.0	0.33	317	10	2.0 × 10−06	7.1	0.32	15	2.6 × 10−13	5.5	0.92

GWAS, genome-wide association study; SNP, single-nulecotide polymorphism; Var Expl, variance explained.

P-values were calculated from 1df Wald statistics χ²-values.

^*Heritability estimate.

^†Fraction of variance explained in the adjusted and transformed phenotype by the top-ranking SNP (SNP with lowest P-value in the combined analysis).

^‡Estimation of the inflation factor for the resulting distribution of P-values.