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. 2014 Aug 19;5:4710. doi: 10.1038/ncomms5710

Figure 1. AF251705−/− mice are more susceptible to CLP-induced peritonitis than WT mice.

Figure 1

(a) WT and AF251705−/− mice (n=15 per group) were subjected to CLP. Mice were monitored every 6 h for 7 days to determine survival. (b) Representative features of the peritoneal cavity of WT or AF251705−/− mice 20 h after CLP. (c) Bacterial numbers in the peritoneal cavity of WT or AF251705−/− mice (n=10 per group) 20 h after CLP. (d) Plasma levels of TNF-α and IL-6 20 h after CLP in WT or AF251705−/− mice (n=10 per group). CFU, colony forming unit. *P<0.05, **P<0.01 (log-rank test in a, Mann–Whitney U-analyses in c and two-tailed Student’s t-test in d). Data are representative of three (a) or two (b–d) independent experiments. Error bars indicate s.d. (c,d).