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. 2014 Aug 19;5:4701. doi: 10.1038/ncomms5701

Figure 2. MK2 regulates synaptic transmission in hippocampal neurons.

Figure 2

(a) AMPAR-dependent mEPSC traces from WT, DKO and DKO neurons expressing EGFP-tagged-MK2-WT (rescue) at baseline. (b) AMPAR-dependent mEPSC events recorded from WT, DKO and DKO neurons expressing MK2-WT and MK3-WT. (c) Cumulative distribution of all mEPSC amplitudes recorded. (d) Mean mEPSC amplitude and (e) frequency showing that the decrease in amplitude and increase in frequency observed in DKO are reversed by re-insertion of MK2-WT. (f) Note that the double peaks in mEPSC amplitude distribution in DKO cells, suggesting multiquantal release, are not seen in WT nor in DKO expressing MK2-WT. Shown are data from WT (n=8 cells), DKO (n=10 cells) and DKO overexpressing MK2-WT (n=6 cells) from three to four independent preparations. Error bars represent ±s.e.m. and *P<0.04; **P<0.01.