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. 2014 Aug 1;4(10):1014–1025. doi: 10.7150/thno.9575

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Typical in vivo animal experiment to estimate the TIC response and corresponding kinetic parameter rate constant α distribution within the selected regions (1: Heavy BBB opening region at the FUS exposure center; 2: mild BBB opening region at the FUS exposure peripheral; 3: normal tissue without FUS exposure). (a) Upper: whole EB dye brain section; lower: 4× enlarged. (b) Corresponding B-mode images after MBs destruction (corresponding to the lower panel of (a)). (c) Corresponding TIC responses at the three selected regions and the estimated α values. Arrow: BBB-opening region.