Table 1.
Incidence of doctor-diagnosed asthma and atopic dermatitis and the point prevalence of respiratory symptoms during the first 6 years and prevalence of sensitization to inhalant allergens at the age of 1 and 6 years
| At 1 year | At 1.5 years | At 2 years | At 3 years | At 4 years | At 5 years | At 6 years | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | n | % | N | n | % | N | n | % | N | n | % | N | n | % | N | n | % | N | n | % | |
| Asthma ever* | 389 | 6 | 1.5 | 353 | 9 | 2.6 | 332 | 14 | 4.2 | 291 | 15 | 5.2 | 271 | 9 | 3.3 | 257 | 6 | 2.3 | 247 | 3 | 1.2 |
| Current asthma† | 353 | 3 | 0.9 | 331 | 7 | 2.1 | 315 | 8 | 2.5 | 290 | 7 | 2.4 | 281 | 3 | 1.1 | 274 | 4 | 1.5 | 270 | 3 | 1.1 |
| Wheezing | |||||||||||||||||||||
| Apart from cold | 391 | 41 | 10.5 | 358 | 24 | 6.7 | 358 | 25 | 7.0 | 338 | 23 | 6.8 | 358 | 29 | 8.1 | 346 | 22 | 6.4 | 357 | 25 | 7.0 |
| Any | 391 | 91 | 23.3 | 358 | 58 | 16.2 | 358 | 67 | 18.7 | 339 | 65 | 19.2 | 358 | 68 | 19.0 | 348 | 46 | 13.2 | 357 | 51 | 14.3 |
| Cough | |||||||||||||||||||||
| Apart from cold | 391 | 98 | 25.1 | 358 | 66 | 18.4 | 358 | 85 | 23.7 | 338 | 80 | 23.7 | 357 | 91 | 25.5 | 348 | 87 | 25.0 | 357 | 94 | 26.3 |
| Nocturnal | 386 | 18 | 4.7 | 358 | 47 | 13.1 | 358 | 76 | 21.2 | 338 | 63 | 18.6 | 357 | 78 | 21.9 | 348 | 59 | 17.0 | 357 | 79 | 22.1 |
| Atopic dermatitis ever‡ | 390 | 61 | 15.6 | 300 | 24 | 8.0 | 265 | 12 | 4.5 | 230 | 14 | 6.1 | 211 | 9 | 4.3 | 199 | 7 | 3.5 | 188 | 2 | 1.1 |
| Sensitization to inhalant allergens§ | 374 | 78 | 20.9 | 304 | 115 | 37.8 | |||||||||||||||
N = in respirtory symptoms: total number of children with information on given symptom at each follow-up; in sensitization: total number of children with IgE results at a given time point; in asthma ever: total number of children at each follow-up who has information on asthma ever at each follow-up and has not censored from the follow-up due to onset of asthma ever; in current asthma: total number of children at each follow-up who has information on asthma ever and asthma medication/any wheezing at each follow-up and has not censored from the follow-up due to onset of current asthma; in atopic dermatitis ever: total number of children at each follow-up who has information on atopic dermatitis at each follow-up and has not censored from the follow-up due to onset of atopic dermatitis. n = the number of children with the presence of wheezing/cough symptom or with positive IgE result, or the number of newly diagnosed asthma/current asthma/atopic dermatitis cases at each follow-up.
Doctor-diagnosed asthma ever is defined as doctor-diagnosed asthma at least once and/or doctor-diagnosed asthmatic bronchitis more than once during the 6-year follow-up.
Current asthma is defined as asthma ever with asthma medication and/or wheezing symptom past 12 months at the age of 6 years.
Atopic dermatitis ever is defined as docotor-diagnosed astopic dermatitis during the follow-up.
Atopic sensitization is defined as any inhalant sIgE ≥0.35 kU/l at the age of 1 year and ≥0.70 kU/l at the age of 6 years.