Skip to main content
. 2014 Aug 22;5:4639. doi: 10.1038/ncomms5639

Figure 1. Gene induction results in rapid diabetes that is normalized by insulin and SU therapy.

Figure 1

(a) Blood glucose levels for 12-week-old βV59M (open circle, black star) and control (black circle, n=41) mice. Mice were injected with tamoxifen (Tx) as indicated by the arrow to induce Kir6.2-V59M expression. Some Tx-injected mice were subsequently implanted with a subcutaneous slow-release placebo pellet at time zero (black star, n=35), whereas others were not (open circle, n=31). (b,c) Blood glucose levels measured in βV59M mice injected with Tx (arrow) and subsequently implanted (arrow) with an insulin pellet (b; open square, n=6) or glibenclamide pellet (c; open triangle, n=19). Control mice (black circle) and Tx-induced untreated βV59M mice (open circle) are the same data as in Fig. 1a. (d) βV59M mice injected with Tx (arrow) and subsequently implanted (arrow) with a glibenclamide pellet (Glib) after 4 weeks of diabetes (open diamond, n=6). Control littermates (black circle, n=6) were sham injected with Tx. Data are mean values±s.e.m.