Fig. 1.

Deformation of the radius and ulna in Chkb^−/− mice. Outward rotational forelimb bone deformation was examined in P7 WT and Chkb^−/− mice (A). Radius and ulna deformations in P0 mice were visualized by skeletal staining of whole body (B) and forelimbs (C) with Alizarin Red and Alcian Blue. Micro-CT imaging was performed on whole body (D) and forelimbs (E). Severe deformation of the radius and ulna in 30-day-old Chkb^−/− mice was visualized by Micro-CT imaging (F). Red arrows indicate deformed radius and ulna in (B) and (D).