Table 1.
Summary of prospective fracture trials evaluating the ability of areal BMD by dual energy X-ray absorptiometry to predict incident fracture
| Study | Study population | N | Follow up | Fracture incidence | Fracture risk and areal BMD |
|---|---|---|---|---|---|
| Yenchek et al 2012 (35) | Elderly patients (age 70–79) with and without CKD (GFR under 60ml/min/1.73m2) | 2754 total 587 with CKD |
11 years | Non-CKD: 13.2% CKD: 16.7% |
Non-CKD: FN BMD (T-Score <2.5) HR 1.64 (95% CI 1.20, 2.25) CKD: FN BMD (T-Score <2.5) HR 2.10 (95% 1.24, 3.59)* |
| Iimori et al 2012 (33) | HD dependent | 485 | 5 years | 1.9 fractures per 100 patient years | Total Hip BMD (per SD) HR 0.65 (95% CI 0.49–0.87) |
| Akaberi et al 2008 (36) | Post renal transplant | 238 | 10 years | 19.3% | Total hip BMD (T-Score <2.5) HR 3.5 (CI 1.8–6.4) |
*
p value for CKD and osteoporosis interaction was not significant