Skip to main content
. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2014 May 27;1842(9):1596–1603. doi: 10.1016/j.bbadis.2014.05.016

Figure 2. Pathogenic mutant LRRK2-transfected neurons show increased dendritic PSD-95 immunoreactivity.

Figure 2

Medium (A) and high (B) power images of GFP/LRRK2 co-transfected neurons immunostained for the glutamatergic postsynaptic marker PSD-95. Many PSD-95 immunoreactive puncta are observed to colocalize with GFP positive dendrites and spines. (C) Composite data showing increased dendritic PSD-95 immunoreactive puncta on dendrites of neurons expressing G2019S LRRK2 (n=26) or R1441C LRRK2 (n=21), but not K1906M LRRK2 (n=25) or WT LRRK2 (* p<0.05 compared to control vector dendrites (n=26), ANOVA: 4 df, F-Ratio: 3.371).

HHS Vulnerability Disclosure