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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2014 May 27;1842(9):1596–1603. doi: 10.1016/j.bbadis.2014.05.016

Figure 3. VGLUT1 immunoreactivity is increased around dendrites of mutant LRRK2-expressing neurons.

Figure 3

Medium (A) and high (B) power images of GFP/LRRK2 co-transfected neurons immunostained for the glutamatergic presynaptic marker VGLUT1. VGLUT1 immunoreactive puncta are observed to abut and colocalize with GFP positive dendrites and spines. (C) Composite data showing increased dendritic VGLUT1 immunoreactivity around dendrites of G2019S LRRK2 (n=36) and R1441C LRRK2 (n=47) transfected neurons but no significant difference around WT LRRK2 or kinase impaired K1906M LRRK2 transfected dendrites (n=38) (* p<0.001 compared to control vector dendrites (n=35), ANOVA: 4 df, F-Ratio: 10.002).

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