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. 2014 Jul 31;15(7):417. doi: 10.1186/s13059-014-0417-z

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© Saraconi et al.; licensee BioMed Central 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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APOBEC1 induces a mutator phenotype in a human chronic myeloid leukemia cell line. Frequency of imatinib-resistant clones arising from 10⁷ K562 cells expressing either mammalian APOBEC1s, AID, or a control plasmid seeded in the presence of 1 μM imatinib (control/APOBEC1, P < 0.05). Imatinib resistance was confirmed by growing the clones in imatinib-supplemented medium.