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. 2014 Aug 11;2014:547480. doi: 10.1155/2014/547480

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Copyright © 2014 Joanna Lecka et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Comparative effect of ticlopidine on recombinant murine NTPDase1. ATPase and ADPase activity of mouse (a) or rat (b) NTPDase1 without and with either 100 μM or 1 mM ticlopidine are presented. The 100% activity with ATP as the substrate in the absence of ticlopidine was 2781 ± 136 and 1502 ± 66 nmol P_i·min⁻¹·mgprotein⁻¹ for mouse and rat NTPDase1, respectively, and with ADP 2219 ± 105 and 1103 ± 56 nmol P_i·min⁻¹·mgprotein⁻¹ for mouse and rat NTPDase1, respectively. Data are presented as the mean ± SD of 3 experiments carried out in triplicate. *P = 0.0049; **P = 0.0007.