Figure 1.
Cumulative survival time of ex vivo perfused lungs. Lung “survival time” represents the time of perfusion at which a lung failure endpoint was met, based on the pre-defined criteria. Lung survival was significantly prolonged in GalTKO.hCD46 lungs compared to wild type (p < 0.001) but not compared to GalTKO lungs (p = 0.27). Autologously perfused lungs survived significantly longer than GalTKO.hCD46 transgenic lungs (+ p = 0.04).