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. Author manuscript; available in PMC: 2014 Aug 26.
Published in final edited form as: J Mol Biol. 2011 Sep 10;413(5):1047–1062. doi: 10.1016/j.jmb.2011.09.001

Fig. 2.

Fig. 2

Overview of the hotspot-centric design strategy. Labels (1A, 1B, etc.) are used in Results to refer to individual steps in the design process. The first two steps, 1 and 2, are divided into two independent design paths, signified by labels A and B.