Table II.
Antigens identified through the screening of ovarian cancer cell lines with individual serum.
| Seroreactivity
|
|||||
|---|---|---|---|---|---|
| KP-OVA-number | Genes (Unigene cluster)a | Source of library and serum | Previously identified by SEREXb | Normal (20) | Ovarian cancer patients (20) |
| 53 | KRT17(Hs.2785) | SNU840/no.14495 | Y | 0/20 | 1/20 |
| 54 | HMGA1(Hs.518805) | SNU840/no.14495 | N | 0/20 | 1/20 |
| 55 | FAM63B(Hs.591122) | SNU840/no.14495 | Y | 3/20 | 1/20 |
| 56 | NHP2L1(Hs.182255) | SNU840/no.14495 | N | 0/20 | 1/20 |
| 57 | TK1(Hs.515122) | SNU840/no.14495 | N | 0/20 | 1/20 |
| 58 | DDB1(Hs.290758) | SNU840/no.14495 | N | 0/20 | 1/20 |
| 59 | NME1(Hs.463456) | SNU840/no.14547 | Y | 0/20 | 1/20 |
| 60 | OGFR(Hs.67896) | SNU840/no.14547 | Y | 0/20 | 1/20 |
| 61 | RPL14(Hs.730621) | SNU840/no.14547 | Y | 0/20 | 1/20 |
| 62 | EIF3S5(Hs.516023 ) | SNU840/no.14547 | N | 0/20 | 1/20 |
| 63 | Hist1h1c(Hs.7644) | SNU840/no.14547 | Y | 0/20 | 1/20 |
| 64 | GUK1(Hs.376933) | SNU840/no.14547 | N | 1/20 | 1/20 |
| 65 | HOMER3(Hs.720208) | SNU840/no.14547 | N | 0/20 | 1/20 |
| 66 | GSDMD(Hs.118983) | SNU840/no.14547 | Y | 0/20 | 1/20 |
| 67 | KIF7(Hs.513134) | SK-OV-3/no.16160 | N | 0/20 | 1/20 |
| 68 | C16orf42(Hs.134846) | SK-OV-3/no.16160 | Y | 0/20 | 3/20 |
| 69 | TINP1(Hs.482526) | SK-OV-3/no.16160 | N | 0/20 | 1/20 |
| 70 | SSNA1(Hs.530314) | SK-OV-3/no.16160 | Y | 1/20 | 5/20 |
| 71 | FTH1(Hs.524910) | SK-OV-3/no.16160 | N | 0/20 | 1/20 |
| 72 | TSPAN4(Hs.654836) | SK-OV-3/no.16160 | Y | 0/20 | 1/20 |
| 73 | S100A4(Hs.654444) | SK-OV-3/no.16160 | Y | 0/20 | 3/20 |
| 74 | PRP6(Hs.31334) | SK-OV-3/no.16160 | Y | 0/20 | 1/20 |
| 75 | MRPS26(Hs.18946) | SK-OV-3/no.16160 | Y | 0/20 | 1/20 |
a
Unigene cluster of isolated antigens (http://www.ncbi.nim.nih.gov/);
b
sequences were compared with those contained in the SEREX database of the Ludwig Institute for Cancer Research (http://ludwig-sun5.unil.ch/CancerImmunomeDB/). Y and N, indicate whether the antigen matched or did not match to an antigen in the SEREX database, respectively.