Table 2.

Time course of the increase of S-adenosyl methionine (SAM) and of its metabolite S-adenosyl homocysteine (SAH) in the cortex of mice receiving methionine (6.6 mmol/kg s.c.)

Treatment	Hours after treatment	SAM	SAH
		pmol/mg protein
Vehicle	1–4	200 ± 7.1	70 ± 10.0
Methionine	1	305 ± 4.0*	142 ± 8.0*
	2	280 ± 3.8*	120 ± 4.0
	4	295 ± 2.1*	100 ± 2.0*

Each value is the mean ± SE of 4–5 mice

^*P <0.01 vs vehicle