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Effects of VPA and various antipsychotics on GAD67 or reelin promoter demethylation in the mouse brain (frontal cortex).
| Drugs | mg/kg | GAD67 or reelin promoter cytosine demethylation | |
|---|---|---|---|
| −VPA | +VPA | ||
| Vehicle | − | +/− | + |
| Clozapine | 1.25 | + | +++ |
| Risperidone | 10 | inactive | inactive |
| Haloperidol | 1.5 | inactive | inactive |
| Olanzapine | 10 | + | ++ |
| Quetiapine | 10 | + | +++ |
VPA: 70 mg/kg
Drugs were given s.c. twice a day for three days
