Skip to main content
. Author manuscript; available in PMC: 2014 Aug 26.
Published in final edited form as: Neuropharmacology. 2010 Nov 11;60(0):1007–1016. doi: 10.1016/j.neuropharm.2010.10.021

Table 5.

Clozapine and valproate (VPA) co-administration reverses the methionine-induced downregulation of frontal cortex GAD67 expression in a methionine-induced epigenetic mouse model of schizophrenia

Treatments GAD67 protein (vs β actin)
Methionine 0.15 ± 0.020*
Methionine + clozapine 0.19 ± 0.015
Methionine + clozapine + VPA 0.35 ± 0.032**
Methionine + VPA 0.29 ± 0.070
VEH 0.38 ± 0.030

GAD67 protein levels (OD ratio of GAD67 to β actin) were determined by Western blot analyses in the frontal cortex of mice treated with methionine (5.2 mmol/kg s.c./twice a day/for 7 days)

VEH, VPA (70 mg/kg), clozapine (5 mg/kg) were administered to mice s.c./twice a day/for 3 days after methionine treatment termination.

Data represent the mean ± SE of 4 mice

*

P<0.01 for methionine vs VEH

**

P<0.01 for methionine vs methionine + clozapine + VPA