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. 2014 Aug 11;2014:157376. doi: 10.1155/2014/157376

Figure 5.

Figure 5

The inhibitory effect of propofol on NADPH oxidase/TNF-α signal pathway in LPS-stimulated myocardium of wild type C57BL/6 mice. Wild type C57BL/6 mice were divided into four groups: control group, propofol alone group, LPS group, and LPS + propofol group. (a) The effect of propofol on gp91phox protein expression in myocardium 2 hours after LPS treatment. (b) Gray intensity analysis of the western blot results of gp91phox expression. (c) The effect of propofol on ERK1/2 phosphorylation in myocardium 1 hour after LPS treatment. (d) Gray intensity analysis of the western blot results of ERK1/2 phosphorylation. (e) The effect of propofol on p38 phosphorylation in myocardium 1 hour after LPS treatment. (f) Gray intensity analysis of the western blot results of p38 phosphorylation. (g) TNF-α protein measurement in myocardium by ELISA at 4 hours after LPS treatment; (h) TNF-α mRNA measurement in myocardium by real time RT-PCR at 2 hours after LPS treatment (each bar represents the mean ± S.D, *P < 0.05, compared with LPS group; n = 5).