Skip to main content
. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Biomaterials. 2014 Jul 18;35(31):8820–8828. doi: 10.1016/j.biomaterials.2014.07.005

Fig. 1. Microstructure fabrication and experiment design.

Fig. 1

Microstructures are fabricated photolithographically by exposure of a thin film of hydrogel polymer to UV energy through a patterned photomask (A). Microrods and microcubes are released from the surface in sterile saline solution (B). From here, the microstructures are either added to a solution of fibroblasts and liquid phase Matrigel to create in vitro 3D tissue constructs for study of cell-microstructure interactions (C), or are injected in saline solution into the infarct zone of Sprague-Dawley rats under ultrasound guidance 48 hours after temporary LAD ligation and reperfusion (D). Light micrographs show high throughput arrays of microrods (E) and microcubes (F) on a silicon wafer. Scale bar = 500 µm.