Table 1.

MIE content in data sets where variants were based on secondary filtering criteria

Data sets	No. of variants	No. of MIE	MIE/variant	Range of MIE per variant	No. of variants with MIEs
PASS	1,607,227	89,542	0.06	0-37	41,489 (2.6%)
Nonbinary	1,796	23,995	13.36	0-37	1,539 (85.7%)
Binary	1,605,431	65,547	0.041	0-22	39,950 (2.5%)