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. 2014 Sep;144(3):221–230. doi: 10.1085/jgp.201411223

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© 2014 Armstrong and Hoshi

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — In two mutants that have C-type inactivation, high extracellular Ca²⁺ depresses I_K. (A) The traces show I_K from a cell expressing T449A during a depolarization lasting 110 ms from −80 to 0 mV. The traces were taken in the order i–iii, with a rest of ∼2 min between them to allow full recovery from C-type inactivation. I_K is strongly depressed by 40Ca0K. Note, however, that the time constant of inactivation of the current remaining in 40Ca0K is similar to that in 2Ca2K. (B) I_K traces from a T449K cell. The extracellular solution was changed from 4Ca2K (i) to 28Ca0K (ii) and then back to 4Ca2K (iii).