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. 2014 Sep;144(3):221–230. doi: 10.1085/jgp.201411223

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© 2014 Armstrong and Hoshi

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Ca²⁺ does not appreciably inhibit currents through T449V channels. (A) Whole-cell currents elicited by pulses from −80 to 50 mV in 4Ca2K and 40Ca0K. (B) Slower activation time course of T449V in 40Ca0K (blue) compared with those in 4Ca2K (black). (C) The currents for pulses from −80 to 0 mV are scaled by 1.3 times to account for the familiar right shift of the I-V curve caused by high Ca²⁺, which is shown in D. (Gilly and Armstrong, 1982; Hille, 2001). All results shown are from the same cell.