Figure 12.

Inward conductance as a function of external [Na⁺] for hASIC1a D434. (A) I-V relationships with different [Na⁺]. NMDG⁺ replaced Na⁺. Currents were normalized to values obtained at V_m = −100 mV with 110 mM NaCl (I₀). In the case of [Na⁺] = 220 mM, the currents were normalized to those obtained at V_m = −100 mV with 110 mM NaCl + 110 mM NMDG·Cl. Data represent means ± SEM for four to five measurements. (B) Inward slope conductance as a function of [Na⁺]. Slope conductances were normalized to values at 110 mM NaCl (G₀) and were fit to the equation G/G_max = [Na⁺]/{[Na⁺] + K_Na}. Best-fit values were G_max = 1.58 and K_Na = 72 mM.