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. 2014 Aug 25;211(9):1793–1805. doi: 10.1084/jem.20131902

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© 2014 Marshall et al.

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Figure 10. — CR2-CD59 treatment prevents mitochondrial depolarization and promotes recovery of ATP stores after 90% PHx. Mice underwent 90% PHx or sham operation, and resected mice were treated with either PBS or CR2-CD59 immediately after surgery. For intravital microscopy study, live animals were infused intravascularly with Rh123 fluorescence and PI (live/dead) stain into the carotid artery 2 h after resection. (A) Representative confocal image of hepatic Rh123 (green) and PI (red). Bars, 10 µM. (B) Percentage of hepatocytes with depolarized mitochondria in 10 high-power fields. Shown are the combined results from 4 independent experiments of 1 mouse per group (mean ± SEM). (C) ATP content in liver tissue taken at different time points after 90% PHx. Results are expressed as mean ± SEM (n = 4–6) and are representative of 3 independent experiments; ***, P < 0.001; **, P < 0.01, as assessed by ANOVA.