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. 2014 Aug 25;211(9):1793–1805. doi: 10.1084/jem.20131902

Figure 3.

Figure 3.

Biodistribution and localization of CR2-CD59 after hepatic IRI. (A) Biodistribution of CR2-CD59 after IRI. 125I-labeled CR2-CD59 was injected into mice immediately after IR or after a sham operation, and tissue distribution of radiolabel was assessed after 2 h reperfusion. Shown are the combined results from 3 independent experiments of 1 mouse per group (mean ± SEM); *, P < 0.05 versus all other samples, as assessed by ANOVA. (B) Hepatic localization of C3d and CR2-CD59 after IRI. CR2-CD59 was injected into WT or CD59−/− mice immediately after IR or after a sham operation, and livers were isolated after 2 h reperfusion. Serial sections were prepared and analyzed by immunohistochemistry for C3d and CR2-CD59 binding. Representative images, n = 3. Bars, 20 µM.