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. 2014 Aug 25;211(9):1793–1805. doi: 10.1084/jem.20131902

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© 2014 Marshall et al.

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Figure 6. — Effect of complement inhibition on outcomes in a model incorporating both IRI and 70% PHx. Mice were treated with PBS, CR2-Crry, or CR2-CD59 immediately after combined surgery. (A) Serum ALT levels. (B) Histological quantification of hepatic necrosis and injury in H&E-stained sections. (C) Hepatic tissue levels of MPO. (D) Assessment of liver regeneration by BrdU incorporation. (E) Liver weight restitution. (F) Mouse survival. All determinations were made 48 h after surgery. (G–J) Hepatic and serum cytokines were measured by ELISA. (G) Hepatic IL-6 levels 3 h after surgery. (H) Hepatic TNF levels 3 h after surgery. (I) Serum IL-6 levels 6 h after surgery. (J) Serum TNF levels 6 h after surgery. Results are expressed as mean ± SEM (n = 4–6) and are representative of 3 independent experiments; ***, P < 0.001; **, P < 0.01, assessed by ANOVA.