Table 1. 99mTc-Probestin Kidney Uptake (% ID/g) at 1 h Postinjection and Histopathology Results of UPII-SV40T Mouse Kidney Sectionsa.
histopathology |
|||||||||
---|---|---|---|---|---|---|---|---|---|
99mTc-probestin uptake |
% renal
pelvis that is occupied by tumor |
% renal
cortex that is occupied by tumor |
|||||||
mouse | genotype | age (wk) | LK | RK | LK | RK | LK | RK | |
1 | transgenic | 63 | 36.6 | 41.0 | 100 | 100 | 5 | 5 | |
2 | transgenic | 57 | 39.0 | 48.3 | 100 | 100 | 1 | 1 | |
3 | transgenic | 57 | 7.6 | 38.6 | 100 | 100 | 50 | 5 | |
4 | transgenic | 25 | 63.1 | 65.4 | 100 | 30 | 5 | 0 | |
5 | transgenic | 25 | 60.0 | 65.1 | 50 | 100 | 0 | 3 | |
6 | transgenic | 80 | 57.1 | 71.3 | 0 | 0 | 0 | 0 | |
7 | transgenic | 80 | 65.4 | 79.3 | 0 | 0 | 0 | 0 | |
8 | transgenic | 50 | 36.0 | 38.2 | 100 | 100 | 5 | 10 | |
9 | transgenic | 25 | 80.1 | 81.2 | 100 | 100 | 1 | 0 | |
10 | wild-type | 60 | 56.5 | 56.6 | 0 | 0 | 0 | 0 | |
11 | wild-type | 80 | 70.2 | 87.1 | 0 | 0 | 0 | 0 | |
12 | wild-type | 25 | 69.6 | 78.6 | 0 | 0 | 0 | 0 |
kidneys | 99mTc-probestin uptake |
---|---|
wild-type mouse kidneys (6 kidneys) | 69.8 ± 12.1 |
transgenic mouse kidneys with no damage of renal cortex (7 kidneys) | 68.5 ± 9.2 |
transgenic mouse kidneys with ≥1% damage of renal cortex (11 kidneys) | 44.9 ± 19.1 |
Mouse 3 is female, and the other mice are male. LK: left kidney. RK: right kidney.