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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Immunol. 2014 Mar 3;192(7):3374–3382. doi: 10.4049/jimmunol.1300237

Figure 5. cDC depletion results in neutrophil release from bone marrow into periphery.

Figure 5

(A–D) DT administration leads to reduced neutrophil number in the bone marrow without affecting total hematopoietic cell number (D). Neutrophil reduction is shown by FACS (A) and graphed as percentage of total CD45+ cell (B) and absolute number (C). (E) Less neutrophil in bone marrow after cDC depletion is confirmed by Naphthol AS-D chloroacetate esterase staining (630×Oil). (F–G) Enhanced neutrophil mobilization into periphery as indicated by increased neutrophil number in blood (F) and increased NDI (G). (H) Increase plasma G-CSF is detected in cDC depleted mice by ELISA.

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