Table 3. Adjusted multivariate Cox proportional hazards model for diabetes progression measured as risk of early insulin prescription redemption in the intensive treatment group and the conventional treatment group.

Intensive group	HR [95% C.I.]	P-value	Conventional group	HR [95% C.I.]	P-value
GRS_Total	1.03 [0.97–1.09]	0.37	GRS_Total	0.88 [0.79–0.98]	0.02
Age at baseline (yrs.)	0.99 [0.95–1.03]	0.59	Age at baseline (yrs.)	0.99 [0.93–1.05]	0.70
Sex (males vs. female)	0.99 [0.55–1.80]	0.98	Sex (males vs. female)	1.16 [0.47–2.88]	0.74
BMI (kg/m2)	1.04 [0.99–1.08]	0.13	BMI (kg/m2)	0.99 [0.92–1.07]	0.85
HbA1c (%)	1.46 [1.30–1.63]	8.63E10−11	HbA1c (%)	1.74 [1.43–2.12]	2.97E10−8
LDL (mmol/L)	1.12 [0.87–1.45]	0.37	LDL (mmol/L)	0.73 [0.48–1.12]	0.15
HDL (mmol/L)	1.09 [0.42–2.81]	0.87	HDL (mmol/L)	0.12 [0.02–0.67]	0.02
TG (mmol/L)	1.31 [1.10–1.56]	2.92E10−3	TG (mmol/L)	0.93 [0.66–1.32]	0.70
Smoking status (non-smokers vs. smokers)	1.00 [0.54–1.84]	0.99	Smoking status (non-smokers vs. smokers)	0.92 [0.40–2.11]	0.84