Table 5. Multivariable Ordinal Logistic Regression Analysis for Risk Factors Associated with Severity of dVRS in BG, WM^*, and Hip.

	dVRS in BG (N = 1028)		dVRS in WM* (N = 894)		dVRS in Hip (N = 1028)
	P value	OR(95% CI)	P value	OR(95% CI)	P value	OR(95% CI)
Age ≥65 years	<0.0001	2.79(2.13–3.67)	0.14	0.81(0.62–1.07)	0.08	1.08(0.82–1.43)
Gender (Male)	0.23	1.18(0.90–1.55)	0.03	1.36(1.03–1.80)	0.01	0.71(0.54–0.93)
History of hypertension	0.39	1.13(0.86–1.47)	<0.0001	2.01(1.54–2.63)	0.30	1.15(0.88–1.51)
NIHSS score at admission ≤3	0.02	1.35(1.06–1.73)	<0.0001	1.86(1.45–2.39)	0.004	0.69(0.54–0.89)
Fazekas score ≥3	<0.0001	2.16(1.63–2.87)	0.93	0.99(0.75–1.30)	0.003	1.55(1.17–2.05)
Lacune	0.02	1.36(1.05–1.78)	0.24	0.85(0.65–1.11)	0.65	1.06(0.81–1.39)
Small-artery occlusion subtype†	0.17	1.20(0.93–1.54)	0.08	0.79(0.61–1.02)	0.006	1.44(1.11–1.86)
dVRS score in WM	<0.0001	1.51(1.33–1.72)			<0.0001	1.73(1.52–1.96)
dVRS score in Hip	<0.0001	1.46(1.23–1.74)	<0.0001	1.92(1.61–2.30)
dVRS score in BG			<0.0001	1.80(1.51–2.16)	<0.0001	1.43(1.21–1.70)

Abbreviations: dVRS, dilated Virchow-Robin Spaces; BG, basal ganglia; WM, white matter; Hip, hippocampus; NIHSS, National Institutes of Health stroke scale; PWMH, periventricular white matter hyperintensities; DWMH, deep white matter hyperintensities.

*The 134 patients with grade 3 PWMH or grade 3 DWMH were excluded.

^†It is contrary to large-artery atherosclerosis subtype of ischemic stroke according to Stop Stroke Study Trial of Org 10172 in Acute Stroke Treatment (SSS-TOAST) classification criteria.