Table 2.

Mean differences (lower 95% confidence interval (CI); upper 95% CI) describing the influence of individual metabolic risk factors on baseline global T₂ (ms) and T₂ progression (ms), with metabolic factors considered one at time adjusted for other OA risk factors^a (A), metabolic factors considered one at time adjusted for BMI and other OA risk factors^a (A1) with all four metabolic factors included in the multivariate regression model (B).

BASELINE T2 Metabolic Factor	A: Individual risk factors	A1: Individual Risk Factors additionally adjusted for BMI	B: All four metabolic factors in the same model
Abdominal circumference	1.3 (0.8; 1.8)	0.4 (−0.2; 1.0)	1.2 (0.7; 1.7)
P-value	P<0.001	P=0.164	P<0.001
Blood pressure	0.5 (0.0;1.0)	0.2 (−0.3; 0.7)	0.2 (−0.3; 0.7)
P-value	P=0.041	P=0.477	P=0.362
Diabetes	2.1 (0.5;3.8)	1.6 (0.0; 3.1)	1.8 (0.2; 2.4)
P-value	P=0.010	P=0.046	P=0.026
Fat consumption	0.7 (0.1;1.3)	0.4 (−0.2; 0.9)	0.5 (−0.1; 1.0)
P-value	P=0.023	P=0.210	P=0.096

T2 PROGRESSION Metabolic Factor	A: Individual risk factors	A1: Individual Risk Factors additionally adjusted for BMI	B: All four metabolic factors in the same model
Abdominal circumference	0.3 (−0.1; 0.7)	0.6 (−1.0; 2.3)	0.2 (−0.2; 0.7)
P-value	P=0.155	P=0.439	P=0.307
Blood pressure	0.2 (−0.2; 0.7)	0.5 (−0.9; 1.8)	0.1 (−0.3; 0.6)
P-value	P=0.367	P=0.507	P=0.0.541
Diabetes	1.3 (−0.1; 2.6)	3.0 (−1.0; 7.0)	1.2 (−0.1; 2.6)
P-value	P=0.060	P=0.145	P=0.080
Fat consumption	0.2 (−0.4; 0.7)	0.3 (−1.2; 1.9)	0.1 (−0.4; 0.6)
P-value	P=0.566	P=0.671	P=0.732

^aAll analyses include other OA risk factors as covariates: age, gender, Herbeden’s nodes at the hands; family history of joint replacement; previous knee surgery; previous knee injury