Table 3.
Adjusted mean differences of baseline global T2 (ms) ±SEM and adjusted mean differences of T2 progression (ms) ±SEM for subjects with ≤2 metabolic factors (n=377) compared with subjects with ≥3 metabolic factors (n=26). P-values are from multivariate regression models adjusted for A: other OA risk factorsa, B: additionally adjusted for continuous BMI.
| BASELINE T2 | T2 PROGRESSION | |||
|---|---|---|---|---|
| Compartment | A | B | A | B |
| Global | 2.0 (1.0; 2.9) <0.001 |
1.2 (0.3, 2.1) P=0.011 |
0.1 (−0.7; 0.9) P=0.828 |
0.1 (−0.8; 0.9) P=0.871 |
| PAT | 1.0 (−0.6; 2.6) P=0.228 |
0.5 (−1.2; 2.2) P=0.570 |
1.3 (−0.3; 2.9) P=0.115 |
1.3 (−0.3 3.0) P=0.112 |
| MFC | 1.4 (0.3; 2.4) P=0.014 |
1.3 (0.1; 2.4) P=0.029 |
0.0 (−1.0; 1.1) P=925 |
0.3 (−0.8; 1.4) P=0.578 |
| LFC | 0.9 (−0.1; 1.9) P=0.076 |
0.9 (−0.2, 1.9) P=0.105 |
0.6 (−0.4; 1.6) P=0.256 |
0.5 (−0.5; 1.6) P=0.308 |
| MT | 3.8 (2.5; 5.1) P<0.001 |
2.4 (1.1; 3.6) P<0.001 |
1.4 (0.1; 2.8) P=0.040 |
0.7 (−0.7; 2.0) P=0.354 |
| LT | 2.3 (0.9; 3.7) P=0.001 |
0.6 (−0.7; 1.8) P=0.387 |
0.1 (−1.0; 1.2) P=0.843 |
0.1 (−1.0; 1.3) P=0.813 |
a
All analyses include other OA risk factors as covariates: Herbeden’s nodes at the hands; family history of joint replacement; previous knee surgery; previous knee injury; age and gender. PAT, patella; MFC, medial femoral condyle; LFC, lateral femoral condyle; MT, medial tibia; LT, lateral tibia.