Table 1.
RNA-Seq analysis identified 190 differentially expressed genes in the Sip1 cKO at E15.5. A value greater than two was used as a cutoff for the un-normalized wild type reads per kilobase per million (RPKM) and Sip1 cKO RPKM means as well as the difference between these means. After normalization, the fold change was calculated and reported here in addition to the p-value (cutoff p < 0.05) and false discovery rate (FDR) p-value correction. The final column (column 8) identifies the expression pattern of each gene during normal development from E10.5 to E12.5 as one of the following groups: significantly downregulated (p < 0.05) in the E10.5 lens compared to the E12.5 lens; significantly upregulated (p < 0.05) in the E10.5 lens compared to the E12.5 lens; not significantly expressed (p > 0.05, detection p-value) in the E10.5 and E12.5 lens as determined by Affymetrix microarrays; not found in the Affymetrix dataset; and expressed but levels are not significantly different between E10.5 and the E12.5 lens.
| Gene ID | Gene Name | Fold Change | p-value | FDR p-value correction | WT RPKM means | Sip1cKO RPKM means | Normal expression change E10.5 to E12.5 | ||
|---|---|---|---|---|---|---|---|---|---|
| Prr15 | proline rich 15 | ? | 1.75E-05 | 1.56E-04 | 0.02 | 2.22 | not significantly expressed | ||
| Ucma | upper zone of growth plate and cartilage matrix associated | 182.3 | 0 | 0 | 0.06 | 14.93 | not significantly expressed | ||
| Adamts15 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15 | 125.3 | 0 | 0 | 0.02 | 2.24 | downregulated | ||
| Mt1 | metallothionein 1 | 81.6 | 0 | 0 | 0.92 | 87.15 | downregulated | ||
| Aass | aminoadipate-semialdehyde synthase | 76.6 | 0 | 0 | 0.14 | 11.85 | downregulated | ||
| Cxcl14 | chemokine (C-X-C motif) ligand 14 | 58.1 | 0 | 0 | 0.08 | 5.08 | downregulated | ||
| Sstr1 | somatostatin receptor 1 | 50.0 | 0 | 0 | 0.08 | 4.67 | not significantly expressed | ||
| Krt8 | keratin 8 | 48.1 | 0 | 0 | 0.07 | 5. 3 3 | downregulated | ||
| Pde6b | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | 42.5 | 0 | 0 | 0.28 | 13.90 | not significantly expressed | ||
| Sntg2 | syntrophin, gamma 2 | 40.5 | 0 | 0 | 0.08 | 3.64 | not significantly expressed | ||
| Igfbp2 | insulin-like growth factor binding protein 2 | 37.8 | 1.58E-09 | 2.40E-08 | 0.70 | 30.86 | downregulated | ||
| Tnnt1 | troponin T1, skeletal, slow | 37.3 | 0 | 0 | 0.23 | 10.12 | downregulated | ||
| Aldh1a3 | aldehyde dehydrogenase family 1, subfamily A3 | 34.7 | 0 | 0 | 0.16 | 6.38 | downregulated | ||
| Dlk1 | delta-like 1 homolog (Drosophila) | 33.0 | 8.06E-11 | 1.41E-09 | 0.27 | 10.67 | downregulated | ||
| Atp7b | ATPase, Cu++ transporting, beta polypeptide | 28.5 | 0 | 0 | 0.10 | 3.18 | upregulated | ||
| Igfbpl1 | insulin-like growth factor binding protein-like 1 | 25.3 | 0 | 0 | 0.97 | 28.98 | not significantly expressed | ||
| Plxna2 | plexin A2 | 23.2 | 0 | 0 | 0.38 | 10.13 | downregulated | ||
| Best3 | bestrophin 3 | 20.9 | 0 | 0 | 0.10 | 2.27 | not found | ||
| Nlgn1 | neuroligin 1 | 16.2 | 0 | 0 | 0.11 | 2.14 | unchanged | ||
| Lgsn | lengsin, lens protein with glutamine synthetase domain | 14.4 | 0 | 0 | 0.06 | 3.63 | not found | ||
| Enc1 | ectodermal-neural cortex 1 | 14.3 | 0 | 0 | 0.81 | 13.73 | downregulated | ||
| Ces1e | carboxylesterase 1E | 14.1 | 0 | 0 | 0.65 | 10.98 | not significantly expressed | ||
| Uchl1 | ubiquitin carboxy-terminal hydrolase L1 | 14.0 | 0 | 0 | 147.49 | 2086.29 | upregulated | ||
| Rgs4 | regulator of G-protein signaling 4 | 11.5 | 0 | 0 | 0.62 | 8.67 | not significantly expressed | ||
| Entpd3 | ectonucleoside triphosphate diphosphohydrolase 3 | 11.2 | 0 | 0 | 0.40 | 5.47 | unchanged | ||
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 10.3 | 0 | 0 | 0.25 | 2.95 | downregulated | ||
| Myh7b | myosin, heavy chain 7B, cardiac muscle, beta | 10.0 | 0 | 0 | 5.11 | 58.64 | not significantly expressed | ||
| Crygs | crystallin, gamma S | 9.1 | 0 | 0 | 416.21 | 3724.74 | upregulated | ||
| Acss2 | acyl-CoA synthetase short-chain family member 2 | 9.0 | 0 | 0 | 0.55 | 6.73 | downregulated | ||
| Chrna4 | cholinergic receptor, nicotinic, alpha polypeptide 4 | 8.8 | 0 | 0 | 1.84 | 19.15 | unchanged | ||
| Ptprcap | protein tyrosine phosphatase, receptor type, C polypeptide-associated protein | 8.6 | 0 | 0 | 0.24 | 2.46 | not significantly expressed | ||
| Ptprt | protein tyrosine phosphatase, receptor type, T | 7.6 | 0 | 0 | 0.41 | 3.80 | downregulated | ||
| Krt18 | keratin 18 | 7.5 | 0 | 0 | 0.58 | 5.27 | downregulated | ||
| Trim55 | tripartite motif-containing 55 | 7.5 | 0 | 0 | 0.55 | 4.92 | not found | ||
| Epn3 | epsin 3 | 7.2 | 0 | 0 | 1.98 | 17.30 | not significantly expressed | ||
| Rbm20 | RNA binding motif protein 20 | 7.2 | 0 | 0 | 0.28 | 2.45 | downregulated | ||
| Fam46b | family with sequence similarity 46, member B | 7.0 | 0 | 0 | 1.55 | 13.59 | not significantly expressed | ||
| Podn | podocan | 6.6 | 0 | 0 | 1.55 | 12.35 | upregulated | ||
| Slc38a5 | solute carrier family 38, member 5 | 6.0 | 0 | 0 | 1.36 | 9.91 | upregulated | ||
| Rgmb | RGM domain family, member B | 5.8 | 0 | 0 | 1.37 | 9.69 | downregulated | ||
| Dsp | desmoplakin | 5.6 | 0 | 0 | 0.38 | 2.60 | downregulated | ||
| Grtp1 | GH regulated TBC protein 1 | 5.4 | 0 | 0 | 2.07 | 13.07 | unchanged | ||
| Wnk2 | WNK lysine deficient protein kinase 2 | 5.2 | 0 | 0 | 2.41 | 14.49 | upregulated | ||
| Gcg | glucagon | 4.9 | 0 | 0 | 26.45 | 152.93 | upregulated | ||
| Rnase4 | ribonuclease, RNase A family 4 | 4.8 | 0 | 0 | 0.47 | 2.57 | downregulated | ||
| Fras1 | Fraser syndrome 1 homolog (human) | 4.7 | 0 | 0 | 0.52 | 2.93 | downregulated | ||
| Hddc3 | HD domain containing 3 | 4.7 | 0 | 0 | 2.45 | 13.90 | downregulated | ||
| Lbh | limb-bud and heart | 4.6 | 0 | 0 | 3.78 | 20.85 | downregulated | ||
| Lrrc16a | leucine rich repeat containing 16A | 4.5 | 0 | 0 | 1.16 | 6.34 | downregulated | ||
| Gsta4 | glutathione S-transferase, alpha 4 | 4.5 | 0 | 0 | 3.39 | 18.47 | downregulated | ||
| Myb | myeloblastosis oncogene | 4.4 | 0 | 0 | 2.73 | 15.30 | downregulated | ||
| Tdrd9 | tudor domain containing 9 | 4.2 | 0 | 0 | 1.31 | 6.82 | not significantly expressed | ||
| Ppp2r2b | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform | 4.1 | 0 | 0 | 1.20 | 6.02 | unchanged | ||
| Plekha7 | pleckstrin homology domain containing, family A member 7 | 3.8 | 0 | 0 | 0.67 | 3.09 | downregulated | ||
| Cyr61 | cysteine rich protein 61 | 3.8 | 2.50E-10 | 4.14E-09 | 0.58 | 2.61 | downregulated | ||
| Edaradd | EDAR (ectodysplasin-A receptor)-associated death domain | 3.8 | 0 | 0 | 0.93 | 4.28 | downregulated | ||
| Rapgef5 | Rap guanine nucleotide exchange factor (GEF) 5 | 3.8 | 0 | 0 | 1.99 | 9.12 | upregulated | ||
| Ckb | creatine kinase, brain | 3.8 | 0 | 0 | 85.35 | 357.31 | upregulated | ||
| Fbxo10 | F-box protein 10 | 3.7 | 0 | 0 | 2.57 | 11.84 | unchanged | ||
| Gmpr | guanosine monophosphate reductase | 3.7 | 0 | 0 | 4.30 | 19.56 | unchanged | ||
| Slc8a1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 3.7 | 0 | 0 | 1.44 | 6.45 | not significantly expressed | ||
| Asap2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 3.6 | 0 | 0 | 2.42 | 11.50 | unchanged | ||
| Cited4 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | 3.6 | 0 | 0 | 3.84 | 16.94 | unchanged | ||
| Sh3bp4 | SH3-domain binding protein 4 | 3.5 | 0 | 0 | 0.97 | 4.15 | downregulated | ||
| R3hdml | R3H domain containing-like | 3.5 | 0 | 0 | 52.37 | 185.59 | not found | ||
| Whrn | whirlin | 3.4 | 0 | 0 | 2.00 | 8.32 | unchanged | ||
| Adcy9 | adenylate cyclase 9 | 3.4 | 0 | 0 | 1.39 | 5.76 | not significantly expressed | ||
| Sox3 | SRY-box containing gene 3 | 3.3 | 0 | 0 | 0.67 | 2.72 | unchanged | ||
| Lingo3 | leucine rich repeat and Ig domain containing 3 | 3.3 | 0 | 0 | 3.21 | 12.69 | upregulated | ||
| Fam132a | family with sequence similarity 132, member A | 3.2 | 0 | 0 | 7.96 | 31.16 | unchanged | ||
| Cbl | Casitas B-lineage lymphoma | 3.2 | 1.13E-13 | 2.60E-12 | 1.12 | 4.35 | unchanged | ||
| Mypn | myopalladin | 3.1 | 0 | 0 | 2.72 | 10.33 | not significantly expressed | ||
| Prkg1 | protein kinase, cGMP-dependent, type I | 3.1 | 0 | 0 | 3.14 | 11.98 | upregulated | ||
| Pgpep1 | pyroglutamyl-peptidase I | 3.1 | 0 | 0 | 11.03 | 40.67 | unchanged | ||
| Cbx6 | chromobox homolog 6 | 3.1 | 0.039 | 0.176 | 1.26 | 3.34 | unchanged | ||
| Rab6b | RAB6B, member RAS oncogene family | 3.1 | 0 | 0 | 2.12 | 7.93 | not significantly expressed | ||
| Apln | apelin | 3.1 | 0 | 0 | 0.93 | 3.52 | upregulated | ||
| Mpp7 | membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) | 3.0 | 0 | 0 | 1.40 | 4.95 | downregulated | ||
| Gpd2 | glycerol phosphate dehydrogenase 2, mitochondrial | 3.0 | 0 | 0 | 1.31 | 4.83 | unchanged | ||
| Zfp111 | zinc finger protein 111 | 3.0 | 0 | 0 | 0.82 | 3.04 | not significantly expressed | ||
| Iqgap1 | IQ motif containing GTPase activating protein 1 | 3.0 | 0 | 0 | 6.14 | 20.86 | downregulated | ||
| Zbtb4 | zinc finger and BTB domain containing 4 | 2.9 | 0 | 0 | 1.47 | 5.15 | upregulated | ||
| Dapl1 | death associated protein-like 1 | 2.9 | 1.97E-05 | 1.74E-04 | 2.91 | 10.10 | unchanged | ||
| Spna1 | spectrin alpha 1 | 2.8 | 0 | 0 | 1.44 | 4.85 | unchanged | ||
| Itgb8 | integrin beta 8 | 2.8 | 0 | 0 | 0.87 | 2.95 | upregulated | ||
| Rassf4 | Ras association (RalGDS/AF-6) domain family member 4 | 2.8 | 0 | 0 | 1.17 | 3.97 | upregulated | ||
| Vill | villin-like | 2.8 | 0 | 0 | 1.26 | 4.28 | unchanged | ||
| Polr2b | polymerase (RNA) II (DNA directed) polypeptide B | 2.8 | 1.67E-06 | 1.74E-05 | 14.31 | 27.86 | downregulated | ||
| Igkc | immunoglobulin kappa constant | 2.7 | 2.04E-11 | 3.83E-10 | 2.39 | 7.82 | unchanged | ||
| Btg2 | B-cell translocation gene 2, anti-proliferative | 2.7 | 0 | 0 | 6.80 | 22.34 | upregulated | ||
| Dsc2 | desmocollin 2 | 2.7 | 8.85E-13 | 1.89E-11 | 1.39 | 4.61 | downregulated | ||
| Stac2 | SH3 and cysteine rich domain 2 | 2.7 | 0 | 0 | 6.38 | 20.70 | upregulated | ||
| Jhdm1d | jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae) | 2.7 | 0 | 0 | 1.83 | 4.12 | unchanged | ||
| Magi2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 2.7 | 0 | 0 | 3.65 | 9.31 | upregulated | ||
| Cmtm7 | CKLF-like MARVEL transmembrane domain containing 7 | 2.6 | 0 | 0 | 7.06 | 23.48 | unchanged | ||
| Neo1 | neogenin | 2.6 | 0 | 0 | 9.54 | 28.47 | unchanged | ||
| Snx29 | sorting nexin 29 | 2.6 | 0 | 0 | 1.14 | 3.55 | not significantly expressed | ||
| Hes6 | hairy and enhancer of split 6 (Drosophila) | 2.6 | 0 | 0 | 7.35 | 22.93 | unchanged | ||
| Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | 2.5 | 0 | 0 | 1.70 | 5.32 | downregulated | ||
| Dusp6 | dual specificity phosphatase 6 | 2.5 | 0 | 0 | 6.56 | 20.05 | downregulated | ||
| Tek | endothelial-specific receptor tyrosine kinase | 2.5 | 0 | 0 | 2.71 | 8.31 | upregulated | ||
| Plxna1 | plexin A1 | 2.5 | 0 | 0 | 7.15 | 14.15 | upregulated | ||
| Ehd4 | EH-domain containing 4 | 2.5 | 0 | 0 | 1.17 | 3.62 | upregulated | ||
| Cyba | cytochrome b-245, alpha polypeptide | -2.5 | 1.30E-06 | 1.37E-05 | 11.12 | 5.28 | upregulated | ||
| mt-Nd6 | mitochondrially encoded NADH dehydrogenase 6 | -2.5 | 3.27E-11 | 6.00E-10 | 1029.84 | 462.16 | not significantly expressed | ||
| Ndufa1 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 | -2.5 | 6.77E-09 | 9.58E-08 | 1097.02 | 466.07 | upregulated | ||
| Adc | arginine decarboxylase | -2.5 | 8.40E-82 | 4.22E-80 | 11.77 | 5.69 | unchanged | ||
| Gstp2 | glutathione S-transferase, pi 2 | -2.6 | 2.06E-15 | 5.42E-14 | 46.96 | 21.19 | upregulated | ||
| Lctl | lactase-like | -2.6 | 1.35E-13 | 3.10E-12 | 31.91 | 14.24 | not significantly expressed | ||
| Cxx1b | CAAX box 1 homolog B (human) | -2.6 | 4.94E-26 | 1.78E-24 | 36.85 | 27.53 | not significantly expressed | ||
| Hnrnpa1 | heterogeneous nuclear ribonucleoprotein A1 | -2.6 | 2.92E-06 | 2.95E-05 | 268.59 | 212.23 | not significantly expressed | ||
| Cnih2 | cornichon homolog 2 (Drosophila) | -2.6 | 1.21E-15 | 3.24E-14 | 23.26 | 11.02 | upregulated | ||
| Pacsin3 | protein kinase C and casein kinase substrate in neurons 3 | -2.6 | 8.77E-38 | 3.65E-36 | 7.90 | 3.70 | unchanged | ||
| Apoo | apolipoprotein O | -2.6 | 2.37E-40 | 1.01E-38 | 17.41 | 12.01 | unchanged | ||
| Tppp3 | tubulin polymerization-promoting protein family member 3 | -2.6 | 5.90E-46 | 2.61E-44 | 33.60 | 15.59 | upregulated | ||
| Hmgn3 | high mobility group nucleosomal binding domain 3 | -2.7 | 6.35E-19 | 1.97E-17 | 170.95 | 71.81 | upregulated | ||
| Malat1 | metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) | -2.7 | 4.80E-16 | 1.32E-14 | 766.15 | 318.63 | upregulated | ||
| Zbtb7b | zinc finger and BTB domain containing 7B | -2.7 | 3.88E-26 | 1.40E-24 | 35.70 | 15.71 | not significantly expressed | ||
| Tecrl | trans-2,3-enoyl-CoA reductase-like | -2.7 | 4.85E-52 | 2.25E-50 | 3.97 | 1.83 | upregulated | ||
| Fgfbp3 | fibroblast growth factor binding protein 3 | -2.7 | 1.10E-56 | 5.19E-55 | 9.15 | 4.24 | upregulated | ||
| Ggct | gamma-glutamyl cyclotransferase | -2.7 | 2.30E-22 | 7.82E-21 | 25.12 | 10.99 | upregulated | ||
| Rpl36a | ribosomal protein L36A | -2.7 | 1.65E-16 | 4.72E-15 | 172.70 | 111.20 | unchanged | ||
| Ceacam10 | carcinoembryonic antigen-related cell adhesion molecule 10 | -2.7 | 2.06E-11 | 3.87E-10 | 15.39 | 7.22 | not significantly expressed | ||
| Cabp5 | calcium binding protein 5 | -2.7 | 1.53E-27 | 5.66E-26 | 4.78 | 2.17 | not significantly expressed | ||
| Pgap2 | post-GPI attachment to proteins 2 | -2.7 | 1.32E-71 | 6.50E-70 | 25.79 | 11.09 | not found | ||
| Pmp22 | peripheral myelin protein 22 | -2.7 | 1.26E-68 | 6.20E-67 | 103.46 | 43.53 | upregulated | ||
| Prdm16 | PR domain containing 16 | -2.8 | 4.67E-21 | 1.55E-19 | 8.79 | 3.75 | unchanged | ||
| Ceacam2 | carcinoembryonic antigen-related cell adhesion molecule 2 | -2.8 | 3.59E-23 | 1.24E-21 | 7.90 | 3.47 | not significantly expressed | ||
| Rnf113a1 | ring finger protein 113A1 | -2.8 | 2.46E-28 | 9.22E-27 | 141.42 | 58.35 | upregulated | ||
| S100a11 | S100 calcium binding protein A11 (calgizzarin) | -2.9 | 8.35E-14 | 1.95E-12 | 57.95 | 22.94 | upregulated | ||
| Ube2v1 | ubiquitin-conjugating enzyme E2 variant 1 | -2.9 | 4.30E-10 | 6.91E-09 | 43.07 | 30.23 | upregulated | ||
| Rnaset2a | ribonuclease T2A | -2.9 | 8.01E-56 | 3.77E-54 | 122.90 | 94.01 | upregulated | ||
| Ngfr | nerve growth factor receptor (TNFR superfamily, member 16) | -3.0 | 1.28E-07 | 1.55E-06 | 9.53 | 3.98 | upregulated | ||
| Rpl17 | ribosomal protein L17 | -3.0 | 7.37E-06 | 6.97E-05 | 338.70 | 174.44 | upregulated | ||
| Nat8l | N-acetyltransferase 8-like | -3.0 | 3.68E-184 | 1.97E-182 | 4.21 | 1.74 | not found | ||
| Tubb2b | tubulin, beta 2B class IIB | -3.0 | 4.25E-82 | 2.14E-80 | 48.31 | 19.53 | upregulated | ||
| Gstm1 | glutathione S-transferase, mu 1 | -3.1 | 5.95E-76 | 2.96E-74 | 95.78 | 39.19 | upregulated | ||
| Tpm2 | tropomyosin 2, beta | -3.1 | 4.98E-24 | 1.74E-22 | 20.20 | 7.88 | upregulated | ||
| Rpl28 | ribosomal protein L28 | -3.1 | 2.96E-40 | 1.26E-38 | 445.60 | 227.01 | unchanged | ||
| Gpx8 | glutathione peroxidase 8 (putative) | -3.2 | 6.70E-09 | 9.49E-08 | 20.35 | 8.93 | unchanged | ||
| Rpl37a | ribosomal protein L37a | -3.2 | 6.43E-20 | 2.06E-18 | 472.52 | 328.77 | downregulated | ||
| Fxyd1 | FXYD domain-containing ion transport regulator 1 | -3.2 | 2.91E-11 | 5.36E-10 | 12.09 | 4.67 | upregulated | ||
| Cyp7b1 | cytochrome P450, family 7, subfamily b, polypeptide 1 | -3.3 | 2.50E-66 | 1.21E-64 | 3.96 | 1.47 | upregulated | ||
| Tubb4 | tubulin, beta 4 | -3.4 | 4.18E-21 | 1.39E-19 | 17.32 | 6. 3 9 | upregulated | ||
| Ccdc23 | coiled-coil domain containing 23 | -3.4 | 1.53E-23 | 5.32E-22 | 76.36 | 27.30 | upregulated | ||
| Pla2g7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | -3.4 | 0 | 0 | 219.38 | 73.90 | upregulated | ||
| Cyb5r2 | cytochrome b5 reductase 2 | -3.4 | 5.52E-79 | 2.76E-77 | 3.79 | 1.38 | not significantly expressed | ||
| Tubb2a | tubulin, beta 2A class IIA | -3.4 | 5.69E-46 | 2.52E-44 | 95.51 | 39.86 | upregulated | ||
| Krt40 | keratin 40 | -3.4 | 4.00E-28 | 1.49E-26 | 3.37 | 1.21 | not found | ||
| Wdr41 | WD repeat domain 41 | -3.4 | 1.27E-247 | 6.85E-246 | 14.38 | 5.00 | upregulated | ||
| Elovl4 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 | -3.5 | 2.07E-88 | 1.06E-86 | 4.01 | 1.40 | upregulated | ||
| Cpt1a | carnitine palmitoyltransferase 1a, liver | -3.6 | 6.95E-20 | 2.22E-18 | 13.96 | 4.74 | upregulated | ||
| Rps29 | ribosomal protein S29 | -3.6 | 6.61E-39 | 2.78E-37 | 595.98 | 313.83 | unchanged | ||
| Slc46a3 | solute carrier family 46, member 3 | -3.7 | 3.53E-100 | 1.83E-98 | 11.63 | 3.95 | not significantly expressed | ||
| Syt5 | synaptotagmin V | -3.7 | 4.03E-61 | 1.93E-59 | 5.24 | 1.74 | not significantly expressed | ||
| Rpl38 | ribosomal protein L38 | -3.7 | 3.89E-55 | 1.82E-53 | 496.75 | 278.37 | unchanged | ||
| Rps28 | ribosomal protein S28 | -3.9 | 6.67E-18 | 2.00E-16 | 315.53 | 106.45 | unchanged | ||
| Trpc6 | transient receptor potential cation channel, subfamily C, member 6 | -3.9 | 2.78E-67 | 1.35E-65 | 22.39 | 6.95 | upregulated | ||
| Dnase2b | deoxyribonuclease II beta | -3.9 | 2.98E-59 | 1.42E-57 | 28.06 | 8.67 | not significantly expressed | ||
| Tmprss11e | transmembrane protease, serine 11e | -4.1 | 5.82E-120 | 3.05E-118 | 9.73 | 2.93 | not significantly expressed | ||
| Rbp3 | retinol binding protein 3, interstitial | -4.2 | 1.32E-10 | 2.25E-09 | 6.69 | 1.97 | upregulated | ||
| Stx11 | syntaxin 11 | -4.3 | 2.22E-44 | 9.72E-43 | 18.36 | 5.30 | not significantly expressed | ||
| Rpl11 | ribosomal protein L11 | -4.3 | 4.53E-31 | 1.76E-29 | 291.83 | 155.91 | unchanged | ||
| Dpysl2 | dihydropyrimidinase-like 2 | -4.4 | 1.39E-79 | 6.95E-78 | 32.94 | 8.78 | downregulated | ||
| Arl5c | ADP-ribosylation factor-like 5C | -4.4 | 1.44E-04 | 1.11E-03 | 3.07 | 0.85 | not found | ||
| Aebp1 | AE binding protein 1 | -4.5 | 4.85E-219 | 2.61E-217 | 6.79 | 1.87 | upregulated | ||
| Rpl19 | ribosomal protein L19 | -4.5 | 5.80E-10 | 9.20E-09 | 338.37 | 299.04 | unchanged | ||
| Pgm5 | phosphoglucomutase 5 | -4.5 | 1.65E-283 | 8.91E-282 | 32.89 | 8.64 | upregulated | ||
| Myo7b | myosin VIIB | -4.5 | 2.33E-35 | 9.46E-34 | 20.19 | 5.25 | upregulated | ||
| Kifc3 | kinesin family member C3 | -4.7 | 4.80E-36 | 1.96E-34 | 4.16 | 1.09 | upregulated | ||
| Faim2 | Fas apoptotic inhibitory molecule 2 | -4.7 | 7.62E-85 | 3.87E-83 | 4.56 | 1.19 | not significantly expressed | ||
| Birc7 | baculoviral IAP repeat-containing 7 (livin) | -5.0 | 1.04E-36 | 4.26E-35 | 37.34 | 9.16 | not significantly expressed | ||
| Hba-x | hemoglobin X, alpha-like embryonic chain in Hba complex | -5.0 | 2.44E-04 | 1.81E-03 | 6.70 | 1.64 | unchanged | ||
| Pappa | pregnancy-associated plasma protein A | -5.0 | 2.13E-40 | 9.09E-39 | 6.03 | 1.43 | not significantly expressed | ||
| Rcan2 | regulator of calcineurin 2 | -5.3 | 2.11E-40 | 9.02E-39 | 10.15 | 2.36 | upregulated | ||
| Ermap | erythroblast membrane-associated protein | -5.3 | 3.66E-305 | 1.99E-303 | 13.11 | 2.99 | unchanged | ||
| Cend1 | cell cycle exit and neuronal differentiation 1 | -5.8 | 3.19E-29 | 1.21E-27 | 4.76 | 1.02 | upregulated | ||
| Scn11a | sodium channel, voltage-gated, type XI, alpha | -6.8 | 9.47E-282 | 5.11E-280 | 7.22 | 1.31 | upregulated | ||
| Rpl39 | ribosomal protein L39 | -6.9 | 3.24E-31 | 1.26E-29 | 489.80 | 259.10 | upregulated | ||
| Ndufb4 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4 | -6.9 | 1.75E-68 | 8.56E-67 | 36.87 | 28.71 | upregulated | ||
| Hba-a2 | hemoglobin alpha, adult chain 2 | -7.2 | 6.67E-13 | 1.44E-11 | 475.53 | 108.94 | not found | ||
| Rpl35a | ribosomal protein L35A | -7.3 | 6.60E-48 | 2.98E-46 | 62.48 | 13.72 | unchanged | ||
| Elavl4 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) | -7.4 | 2.01E-97 | 1.04E-95 | 2.93 | 0.49 | not significantly expressed | ||
| Cnrip1 | cannabinoid receptor interacting protein 1 | -7.4 | 7.37E-160 | 3.93E-158 | 5.05 | 0.80 | upregulated | ||
| Ccdc109b | coiled-coil domain containing 109B | -8.0 | 7.80E-19 | 2.41E-17 | 2.36 | 0.35 | not significantly expressed | ||
| Actn2 | actinin alpha 2 | -9.5 | 3.84E-12 | 7.82E-11 | 8.77 | 1.14 | not significantly expressed | ||
| Stmn4 | stathmin-like 4 | -10.0 | 2.27E-65 | 1.09E-63 | 2.95 | 0.34 | upregulated | ||
| mt-Atp6 | mitochondrially encoded ATP synthase 6 | -10.6 | 7.68E-48 | 3.46E-46 | 877.78 | 156.86 | not found | ||
| Rpl34 | ribosomal protein L34 | -24.5 | 7.09E-84 | 3.60E-82 | 215.28 | 98.65 | upregulated | ||
| Hist1h2af | histone cluster 1, H2af | -? | 2.83E-09 | 4.17E-08 | 4.52 | 0.03 | not found | ||