Table 1. Effects of 1 year of growth hormone replacement therapy on clinical variables, IGF-I levels and extracellular water volume (ECW) assessed by bioimpedance (BIA).
| Baseline | 1 year | Change | P-value | |
| Weight (kg) | 83.2±18.4 | 82.7±18.3 | -0.5±6.3 | 0.177 |
| BMI (kg/m2) | 28.7±5.3 | 27.4±5.2 | -1.3±2.1 | 0.07 |
| SBP (mmHg) | 129.4±18.5 | 127.6±17.7 | -1.7±15.0 | 0.045 |
| DBP (mmHg) | 79.0±10.1 | 77.6±10.2 | -1.5±9.4 | 0.007 |
| IGF-I (µg/L) | 107.5±69.3 | 252.8±122.7 | 145.2±100.8 | <0.0001 |
| IGF-I SDS | -1.2±1.2 | 0.9±2.5 | 2.1±2.3 | <0.0001 |
| ECWBIA (L) | 17.3±4.3 | 17.8±4.3 | 0.5±1.2 | <0.0001 |
Data are presented as mean ± SD. Change (1 year minus baseline). BMI, body mass index. SBP: systolic blood pressure; DBP: diastolic blood pressure. SDS, standard deviation score.