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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Neurobiol Dis. 2014 Jun 27;70:214–223. doi: 10.1016/j.nbd.2014.06.014

Figure 3.

Figure 3

A single subclinical dose of rotenone induced mtDNA damage in rat VMB but not cortex in vivo. (a) 24 hours following a single injection of rotenone, mtDNA lesions were induced in the VMB (*p < 0.001, Student's t-test). In contrast, rotenone reduced mtDNA lesions in the cortex (*p < 0.05, Student's t-test). (b) Sublethal rotenone exposure did not alter mtDNA copy number in VMB or cortex relative to vehicle with a single rotenone injection. Data are presented as mean ± SEM. The QPCR-based assay was performed in technical triplicate for each biological replicate (n = 8 vehicle, n = 9 rotenone for VMB; n = 6 vehicle, n = 6 rotenone for cortex).