Fig. 1.

The GnRH expression network was decreased in the hypothalamus of female largemouth bass (LMB) after treatment with MeHg. The expression of genes in this network decreased by an average of 10%. Red indicates increased gene expression with MeHg treatment while green indicates that gene expression is decreased in response to MeHg exposure. Abbreviations: CASP3: caspase 3, apoptosis-related cysteine peptidase; CCND2: cyclin D2; CD9: CD9 molecule; CGA: glycoprotein hormones, alpha polypeptide; CIDEA: cell death-inducing DFFA-like effector a; CYP26A1: cytochrome P450, family 26, subfamily A, polypeptide 1; FOS: FBJ murine osteosarcoma viral oncogene homolog; FSHB: follicle stimulating hormone, beta polypeptide; GAD1: glutamate decarboxylase 1 (brain, 67 kDa); GH1: growth hormone 1; GNRHR: gonadotropin-releasing hormone receptor; IGF1: insulin-like growth factor 1 (somatomedin C); LHB: luteinizing hormone beta polypeptide; MYF5: myogenic factor 5; MYOD1: myogenic differentiation 1; NFKBIA: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; NPY: neuropeptide Y; NRIP1: nuclear receptor interacting protein 1; PCK2: phosphoenolpyruvate carboxykinase 2 (mitochondrial); PECR: peroxisomal trans-2-enoyl-CoA reductase; PENK: proenkephalin; PITX1: paired-like homeodomain 1; PITX2: paired-like homeodomain 2; POMC: proopiomelanocortin; PRL: prolactin; PROP1: PROP paired-like homeobox 1; PTPN6: protein tyrosine phosphatase, non-receptor type 6; PTTG1: pituitary tumor-transforming 1; RASAL1: RAS protein activator like 1 (GAP1 like); SCG2: secretogranin II; SDHC: succinate dehydrogenase complex, subunit C, integral membrane protein, 15 kDa; SSTR2: somatostatin receptor 2; STAR: steroidogenic acute regulatory protein; TAGLN: transgelin; TCF21: transcription factor 21; TGFB1: transforming growth factor, beta 1; TH: tyrosine hydroxylase; THRA: thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); VEGFA: vascular endothelial growth factor A.