Table 1.

Sub network enrichment analysis for disease networks with altered gene expression in common in both the female largemouth bass (LMB) hypothalamus laboratory MeHg injection study and the female LMB whole brain field study. The complete list of significantly regulated disease sub-networks is presented in Appendix 2.

Disease	Total # of neighbors	# of Measured neighbors	Median change whole brain	p-Value whole brain	Median change HYP	p-Value HYP
Activated protein C  resistance	10	6	−1.252	0.034	−1.102	0.024
Alveolus morphology	16	5	1.958	0.005	−1.750	0.016
Amenorrhea	14	7	−1.443	0.007	−1.897	0.016
Critical illness	23	6	−1.582	0.042	−1.124	0.050
Endocrine system diseases	21	9	−1.157	0.039	−1.897	0.002
Evoked potential	129	21	−1.198	0.047	1.121	0.007
Gestational age	161	19	−1.206	0.003	−1.287	0.009
Hypopituitarism	18	7	−1.582	0.008	−3.338	0.002
Intestinal diseases	70	12	1.401	0.012	1.062	0.032
Liver mass	26	8	1.440	0.010	−1.287	0.018
Lordosis	56	10	1.251	0.026	−1.580	0.035
Pituitary neoplasms	121	22	−1.224	0.001	−1.076	0.016
Podocyte infiltration	33	6	1.440	0.038	−1.287	0.034
Prolactinoma	34	8	1.440	0.004	−1.287	0.006
Puberty, precocious	20	8	1.312	0.024	−1.313	0.008
Testis size	20	7	−1.389	0.038	−1.472	0.003
Thymus involution	41	12	1.440	0.030	−1.445	0.030