. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: Ophthalmology. 2014 May 6;121(9):1818–1826. doi: 10.1016/j.ophtha.2014.03.020

Table 6.

Relationship between preterm optic nerve parameters at 37–42 weeks with indicators of central nervous system pathology

Parameters	vDiscDiam (μm)		vCupDiam (μm)		vC:D		Cup Depth (μm)

	Mean (SD)	P-value^*	Mean (SD)	P-value^*	Mean (SD)	P-value^*	Mean (SD)	P-value^*

IVH
Y (24/44)	1301 (145)	0.786	916 (189)	0.396	0.70 (0.19)	0.444	430 (207)	0.671
N (20/44)	1294 (150)	0.786	852 (257)	0.396	0.65 (0.15)	0.444	443 (159)	0.671
Post-hemorrhagic
Hydrocephalus
Y (7/44)	1239 (106)	0.149	1006 (297)	0.344	0.81 (0.20)	0.112	331 (59)	0.030
N (37/44)	1309 (151)	0.149	864 (267)	0.344	0.65 (0.16)	0.112	456 (194)	0.030
PVL
Y (10/44)	1275 (152)	0.674	1084 (222)	0.005	0.85 (0.13)	<0.001	447 (209)	0.654
N (34/44)	1304 (146)	0.674	828 (262)	0.005	0.63 (0.15)	<0.001	433 (180)	0.654
PVL or post-hemorrhagic
Hydrocephalus
Y (12/44)	1261 (141)	0.280	1022 (248)	0.042^**	0.81 (0.15)	0.004	421 (199)	0.292
N (32/44)	131 (147)	0.280	836 (269)	0.042^**	0.63 (0.16)	0.004	442 (182)	0.292
MRI performed
Y (19/44)	1305 (162)	0.713	966 (314)	0.066	0.73 (0.19)	0.023	425 (212)	0.485
N (25/44)	1292 (136)	0.713	827 (227)	0.066	0.64 (0.15)	0.023	445 (165)	0.485
Head Circumference
Drop Off
Y (5/23)	1349 (141)	0.823	941 (262)	0.551	0.70 (0.16)	0.8815	527 (254)	0.602
N (18/23)	1331 (172)	0.823	917 (342)	0.551	0.68 (0.20)	0.8815	442 (188)	0.602

Wilcoxon Rank Sums test, 1-tailed

^**

On repeat analysis with cup offset 150 μm above the disc plane, p=0.069; all other statistical values remain unchanged in significance

Y, present; N, absent

IVH, intraventricular hemorrhage; PVL, periventricular leukomalacia; MRI, magnetic resonance imaging

vDiscDiam, vertical disc diameter; vCupDiam, vertical cup diameter; vC:D, vertical cup-to-disc ratio

SD, standard deviation