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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Biol Psychiatry. 2014 Feb 26;76(10):794–801. doi: 10.1016/j.biopsych.2014.02.012

Figure 3. P11 overexpression prevents cocaine induced c Fos activation in the NAc.

Figure 3

(A) The position of the NAc region used for quantification is indicated by grey square at 1.18 mm from Bregma according to Franklin and Paxinos (2008). (B) c-Fos immunoreactivity in the NAc core of control (AAV-YFP) or AAV-p11 infected mice 2 hrs after the last saline or cocaine injection of a 10 day treatment. White arrows indicate infected cells, note strong c-Fos induction after cocaine treatment in YFP infected cells, and decreased c-Fos induction by cocaine in p11 infected neurons. Scale bar 50 µm. (C) quantification of c-Fos positive cells within the infected area. Data (means ±SEM n=6–10 per group) were analyzed using two way ANOVA. Effect of injected virus F(1, 28)= 9.23, p=0.0055; effect of drug treatment F(1, 28)= 11.46, p=0.0024; interaction F(1, 28)= 0.16, NS. Post hoc comparison (Tukey HSD test) **p<0.01.