Figure 9.

Model of Intracellular Trafficking System in Plants and the Response to BFA.

BFA-sensitive GNOM localizes with BFA-resistant GNL1 to distinct but partially overlapping subdomains of the Golgi apparatus. GNOM regulates vesicle budding at the Golgi apparatus and indirectly regulate recycling of PM cargos through maintaining the function of TGN/EE. TGN or its subdomain is a good candidate for recycling endosomes. BFA causes gradual translocation of GNOM from Golgi stacks to TGN/EE. During this process, BFA indirectly inhibit recycling pathways (marked by asterisk). Minor population of GNOM and GNL1 also revealed to localize at PMs to mediate endocytosis. Dotted arrows represent the inhibited trafficking pathway.