Figure 1.

Chemical structure of BACE inhibitor RO5508887 (A) and its in vivo potency in wild-type, APPLon and APPsw mice (B). Reduction of total brain Aβ40 was determined in an acute study were the animals were killed 4 h post-treatment. Each bar represents the mean of three to four animals, Young, preamyloid mice were used for this comparative study to determine the changes of soluble brain Aβ following acute BACE inhibition with RO5508887. wt, wildtype C57BL/6 mice; APPLon, hAPPV717I; APPsw, hAPPKM670/671NL.