Fig. 4.

Role of NFκB in cytokine-induced β cell death. a INS-1E cells and b mouse islets were cultured for 48 h in the absence or presence of cytokines (IL-1β, TNF-α, and IFN-γ) (3mix) and with andrographolide (5–50 μM) (Andro_5–50) as indicated before determination of cell viability. a Results are mean ± SEM (n = 8), *P < 0.001 versus 3mix, b Results are mean ± SEM (n = 4), *P < 0.05 versus control, **P < 0.05 versus 3mix