Fig. 8.

Effects of DRB on HDACs 1–3 phosphorylations. INS-1E cells were cultured for 30 min or 2 h in the absence or presence of cytokines (IL-1β, TNF-α, and IFN-γ) (3mix) and DRB (50 μM) (DRB₅₀) as indicated. a HDAC1 phosphoserine 421/423 (pHDAC1_ser421/423), b HDAC2 phosphoserine 394 (pHDAC2_ser394), c HDAC3 phosphoserine 424 (pHDAC3_ser424). Results are mean ± SEM (n = 3–5) with a representative experiment shown below bars